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When HCC cells were cocultured with fibroblasts, a tumor-stroma interaction system mimicking in vivo situation, HCC cells exhibited an enhanced invasive ability, suggesting that some interactions between cancer cells and fibroblasts can promote the tumor invasion.

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The mice were sacrificed and the tumors were resected under aseptic conditions, put into MEM medium with 0.

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Despite the close correlation between CD expression and malignancy of some tumors, it is not clear whether CD has a functional role in tumor genesis and hepatocellular carcinoma HCC progression.

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